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Synthesis and pharmacological study of 1,3-dihydro-1,3-dimethyl-5-phenyl-7-nitro-2H-1,4-benzodiazepin-2-one

✍ Scribed by A. N. Grinev; É. S. Krichevskii; O. B. Romanova; A. I. Ermakov; I. K. Sokolov; M. D. Mashkovskii

Book ID: 112400665
Publisher: Springer
Year: 1983
Tongue: English
Weight: 375 KB
Volume: 17
Category: Article
ISSN: 0091-150X
DOI: 10.1007/bf00765129

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## Abstract The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near