Synthesis and pharmacological properties of some substituted 1,5-benzodiazocin-2-ones

✍ Scribed by Martin Steinman; John G. Topliss

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 365 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600580706

✦ Synopsis

Some substituted 8-chloro-3,4-dihydro-6-phenyl-1,5benzodiazocin-2-ones, which are structurally related to the antianxiety agent diazepam, have been synthesized and their central nervous system properties evaluated. Activity was observed for compounds bearing a methyl substituent at position one which was of a lower order of magnitude than that shown by diazepam. R I c1 q -C,H, IIIa,b Keyphrases 0 1,5-Benzodiazocin-2-ones, substituted-ynthesis 0 Pharmacological screening-l,5-benzodiazocin-2-ones 0 UV spectrophotometry-identity 0 1R spectrophotometry-identity 0 NMR spectroscopy-identity

In view of the marked sedative, muscle relaxant, and anticonvulsant properties in animals of various compounds derived from the benzodiazepinone ring system (I), and the therapeutic utility of certain members of this class such as diazepam (I), it was of interest to determine the activities of structurally similar compounds in the benzodiazocine series.