The in uiuo metabolism of 2-ethyl-2,3-dihydro-5-benzofuranacetic acid (furofenac), a new drug, was studied in rats, dogs, and humans. The drug has antiplatelet-aggregation activity and anti-inflammatory activity combined with low dcerogenic power. Hydroxylated derivatives and analogous compounds wer
Synthesis and pharmacological properties of 4(5)-(2-ethyl-2,3-dihydro-2 silainden-2-yl)imidazole, a silicon analogue of atipamezole
✍ Scribed by P Heinonen; H Sipilä; K Neuvonen; H Lönnberg; VB Cockcroft; S Wurster; R Virtanen; MKT Savola; JS Salonen; JM Savola
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 491 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0223-5234
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A simple method for the synthesis of various 3-(4,5-dihydro-1H-imidazole-2-yl)-1H-indoles is described. Treatment of different substituted indoles with 1-acetyl-imidazolidin-2-one in the presence of phosphorus oxychloride afforded after hydrolysis in ethanol the corresponding 3-(4,5-dihydro-1H-imida
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