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Synthesis and pharmacological investigation of azaphthalazinone human histamine H1 receptor antagonists

โœ Scribed by Panayiotis A. Procopiou; Christopher Browning; Paul M. Gore; Sean M. Lynn; Stephen A. Richards; Robert J. Slack; Steven L. Sollis


Book ID
118003450
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
483 KB
Volume
20
Category
Article
ISSN
0968-0896

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The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding