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Synthesis and Pharmacological Identification of Neutral Histamine H 1 -Receptor Antagonists

โœ Scribed by Govoni, Marinella; Bakker, Remko A.; van de Wetering, Ineke; Smit, Martine J.; Menge, Wiro M. B. P.; Timmerman, Henk; Elz, Sigurd; Schunack, Walter; Leurs, Rob


Book ID
127048727
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
183 KB
Volume
46
Category
Article
ISSN
0022-2623

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The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H2 and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H2 and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding