Synthesis and pharmacological investigation of 1-substituted 2-cyaniminopyrrolidines that are structurally related to piracetam
β Scribed by D. B. Nilov; A. V. Kadushkin; V. G. Granik; N. P. Solov'eva; V. V. Asnina; R. B. Parimbetova; V. A. Parshin; M. D. Mashkovskii
- Book ID
- 112405424
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 439 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0091-150X
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## Abstract A series of new 1β, 2β and 3βpiperazinylbenzothieno[2,3β__d__]triazole derivatives structurally related to Trazodone were prepared and tested for their antiserotonergic, antiadrenergic and antihistaminergic __in vitro__ activities together with their analgesic __in vivo__ activity by us
Quarternary salts based upon 3-alkyl substituted 1-amino-1,2,3-triazolium cations (alkyl = methyl, ethyl, n-propyl, 2-propenyl, and n-butyl) have been synthesized and characterized by vibrational spectra, multinuclear NMR, elemental analysis, and DSC studies. Subsequent diazotization of these salts