✦ LIBER ✦

Synthesis and biological activity of 1-, 2- or 3-Substituted benzothieno-[2,3-d]triazole derivatives structurally related to trazodone

✍ Scribed by Francesco Guerrera; Loredana Salerno; Maria Concetta Sarvà; Maria Angela Siracusa; Antonino Corsaro; Venerando Pistarà; Raffaele Capasso; Giuseppina Mattace Raso

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 376 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360235

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A series of new 1‐, 2‐ and 3‐piperazinylbenzothieno[2,3‐d]triazole derivatives structurally related to Trazodone were prepared and tested for their antiserotonergic, antiadrenergic and antihistaminergic in vitro activities together with their analgesic in vivo activity by using Trazodone as the reference compound.

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