๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis and Pharmacological Characterization of Chiral Pyrrolidinylfuran Derivatives: The Discovery of New Functionally Selective Muscarinic Agonists

โœ Scribed by Scapecchi, Serena; Nesi, Marta; Matucci, Rosanna; Bellucci, Cristina; Buccioni, Michela; Dei, Silvia; Guandalini, Luca; Manetti, Dina; Martini, Elisabetta; Marucci, Gabriella; Romanelli, Maria Novella; Teodori, Elisabetta; Cirilli, Roberto


Book ID
126306439
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
608 KB
Volume
51
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Design, Synthesis, and Pharmacological C
โœ Dr. Clelia Dallanoce; Dr. Pietro Magrone; Dr. Carlo Matera; Dr. Fabio Frigerio; ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 640 KB

## Abstract A set of racemic spirocyclic quinuclidinylโ€ฮ”^2^โ€isoxazoline derivatives was synthesized using a 1,3โ€dipolar cycloadditionโ€based approach. Target compounds were assayed for binding affinity toward rat neuronal homomeric (ฮฑ7) and heteromeric (ฮฑ4ฮฒ2) nicotinic acetylcholine receptors. ฮ”^2^โ€