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Synthesis and pharmacological characterization of a new benzoxazole derivative as a potent 5-HT3 receptor agonist

✍ Scribed by Pedro Luis López-Tudanca; Luis Labeaga; Ana Innerárity; Luisa Alonso-Cires; Inés Tapia; Ramón Mosquera; Aurelio Orjales


Book ID
108479355
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
219 KB
Volume
11
Category
Article
ISSN
0968-0896

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A series of novel aryl aminosulfonamides was designed and synthesized as 5-HT 6 receptor ligands. Many compounds screened in a functional reporter gene based assay displayed potent antagonistic activity with Kb values in the range of 0.02-10 nM. The lead compound 11m exemplified in this series showe