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Synthesis and pharmacological characterization of a series of leukotriene analogs with antagonist and agonist activities

✍ Scribed by Bernstein, Peter R.; Vacek, Edward P.; Adams, Edward J.; Snyder, David W.; Krell, Robert D.

Book ID
126219049
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
698 KB
Volume
31
Category
Article
ISSN
0022-2623

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## E-and Z-enynes available by stereoselective dehydrations of Co2(CO) complexed and uncomplexed propargyl alcohols 13 and 5 produced acetylenic LT-E4 analogs with !! ontractile activity similar to leukotrienec Their 5-desoxy analogs were found to have antagonist activity against LT-C4 induced con