𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and pharmacological activity of philanthotoxin-343 analogs: Antagonists of ionotropic glutamate receptors

✍ Scribed by Danwen Huang; Hong Jiang; Koji Nakanishi; P.N.R. Usherwood


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
655 KB
Volume
53
Category
Article
ISSN
0040-4020

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of conformationally-constraine
✍ Frédérique Tellier; Francine Acher; Isabelle Brabet; Jean-Philippe Pin; Joël Boc 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 332 KB

Rigid analogs of ACPD have been synthesized to mimick different potential conformations of ACPD in aqueous solution. One of them, (+)-ABHD-I is a competitive antagonist at mGluRla receptor with a KB value of 300 laM. Glutamic acid is a major excitatory amino acid and neurotransmitter in the central