Synthesis and pharmacological characterization of 5-phenyl-2-[2-(1-piperidinylcarbonyl)phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones: A new class of Neuropeptide S antagonists
โ Scribed by Fabrizio Micheli; Romano Di Fabio; Angelo Giacometti; Adelheid Roth; Elisa Moro; Giancarlo Merlo; Alfredo Paio; Emilio Merlo-Pich; Silvia Tomelleri; Federica Tonelli; Paola Zarantonello; Laura Zonzini; Anna Maria Capelli
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 378 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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## Abstract Fused tricyclic 7โphenylโ5__H__โthizolo[5,4โ__e__]pyrrolo[1,2โ__a__][1,4]diazepinโ10(9__H__)one (**10**) was prepared by thermolysis of 2โphenylโ4โ(1โpyrrolylmethyl)thiazoleโ5โcarbonyl azide (**9**) in acetic acid. In addition, starting from **10**, 7โphenylโ5__H__โthiazolo [5,4โ__e__][
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonโ14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cโbenzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des