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An expedient synthesis of 3-amino-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one

✍ Scribed by Mark G Bock; Robert M DiPardo; Ben E Evans; Kenneth E Rittle; Daniel F Veber; Roger M Freidinger

Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
204 KB
Volume
28
Category
Article
ISSN
0040-4039

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The synthesis of 7-chloro-1-methyl-5-phenyl-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C and 7-nitro-1-methyl-5-(2′-fluorophenyl)-1, 3-dihydro-2H-1,4-benzodiazepin-2-one-5-14C
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## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des