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Synthesis and optimization of 1-pyrrolemethane sulfonate by means of experimental design

✍ Scribed by Per M. Andersson; Torbjörn Lundstedt; Lisbeth Abramo

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
274 KB
Volume
10
Category
Article
ISSN
0886-9383

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✦ Synopsis

This paper gives one approach of how to use experimental design in order to increase the yield for an organic synthesis. In this case the synthesis of 1-pyrrolemethane sulfonate was optimised. Two types of designs were used. First a series of screening experiments using fractional factonal design was applied.

From these experiments a model was determined and used to locate the next experimental domain. The following experiments were planned as a Doehlert design in order to obtain a response surface model. "he optimum was estimated and confirmed experimentally. O 1996 by John Wiley & Son, Ltd.

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