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Synthesis and optical resolution of dl-cis-2-fluorocycloproplylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859

✍ Scribed by Osamu Tamura; Masaru Hashimoto; Yuko Kobayashi; Tadashi Katoh; Kazuhiko Nakatani; Masahiro Kamada; Isao Hayakawa; Toshifumi Akiba; Shiro Terashima

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 276 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)92669-8

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✦ Synopsis

The title synthesis was accomplished by featuring highly cis-selective cyclopropanation of an Nvinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2fluorocyclopropyl)m&amate. Optical resolution of~-cis-2-~~ro~clopropyhnrinc was also achiewd by employing lmenthyl chlordormate as a resolving agent.

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