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Asymmetric synthesis of (1R,2S)-2-fluorocyclopropylamine, the key intermediate of the new generation of quinolonecarboxylic acid, DU-6859

✍ Scribed by Osamu Tamura; Masaru Hashimoto; Yuko Kobayashi; Tadashi Katoh; Kazuhiko Nakatani; Masahiro Kamada; Isao Hayakawa; Toshifumi Akiba; Shiro Terashima

Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
311 KB
Volume
33
Category
Article
ISSN
0040-4039

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✦ Synopsis

The title synthesis was achieved by featuring diastereoface selective cyclopropanation of (4RE%4.5diphenyl-3-vinyl-2-oxazolidinonc. the chiral and conformationally rigid N-vinylcarbamate, with zincmonofuorocarbenoid followed by hydrogenolysis of formed (4R~S)-3-[(1R2S)-2-fluorocyclopropylI~5-diphenyl-2oxawlidinone.

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