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Synthesis and opioid activity of partial retro-inverso analogs of dermorphin

✍ Scribed by SALVADORI, SEVERO ;MARASTONI, MAURO ;BALBONI, GIANFRANCO ;SARTO, GIANPIETRO ;TOMATIS, ROBERTO


Book ID
115098332
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
509 KB
Volume
25
Category
Article
ISSN
0367-8377

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Solid-phase synthesis of partially-modif
✍ Alessandro Volonterio; Pierfrancesco Bravo; Nathalie Moussier; Matteo Zanda * πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 193 KB

The solid-phase synthesis of a novel class of retro and retro-inverso peptides featuring a 2[NHCH(CF 3 )] surrogate of the classical (NHΓ€CO) retro-peptide bond has been accomplished. Wang resin bound a-amino esters 2 were engaged in Michael-type N-additions with 3-(E-enoyl)-1,3-oxazolidin-2one 3, wh