An efficient synthesis of pyridine conta
β
Jean-Michel Siaugue; Fabienne Segat-Dioury; Alain Favre-RΓ©guillon; Charles Madic
π
Article
π
2000
π
Elsevier Science
π
French
β 104 KB
Reaction of diethylenetriamine with 2-nitrobenzenesulfonyl chloride leads to an activated and protected compound that could be cyclized to N-protected aza-macrocycle. After a smooth deprotection step, the macrocycle was alkylated with chloroacetic acid leading to the pyridine containing triaza-macro