Synthesis and NMR elucidation of novel penta-cycloundecane amine derivatives as potential antituberculosis agents

✍ Scribed by Oluseye K. Onajole; Thavendran Govender; Maya Makatini; Hendrik G. Kruger

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 164 KB
• Volume: 46
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.2305

✦ Synopsis

Abstract

The synthesis and NMR elucidation of five novel penta‐cycloundecane amine derivatives are reported. These compounds are potential antituberculosis agents. The ^1^H and ^13^C spectra showed major overlapping of methine signals of the cage skeleton making it extremely difficult to elucidate these compounds. The overlapping occurs as a result of the additions made to the carbonyl carbon (C‐8/C‐11) of the cage. The two‐dimensional NMR technique proved to be a useful tool in overcoming this problem. All compounds reported are meso compounds thereby not only simplifying the NMR structure elucidation, but also making it indeed possible. Copyright © 2008 John Wiley & Sons, Ltd.