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Synthesis and NMR-Driven Conformational Analysis of Taxol Analogues Conformationally Constrained on the C13 Side Chain

✍ Scribed by Barboni, Luciano; Lambertucci, Catia; Appendino, Giovanni; Vander Velde, David G.; Himes, Richard H.; Bombardelli, Ezio; Wang, Minmin; Snyder, James P.


Book ID
120552169
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
154 KB
Volume
44
Category
Article
ISSN
0022-2623

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## Abstract Solid‐state NMR spectroscopy was applied to the analysis of melanins prepared by peroxidase‐H~2~O~2~ oxidation of dopamines specifically ^13^C labelled in the α‐ or β‐side chain positions. A surprisingly diverse pattern of signals indicated the presence of uncyclized dopamine and noradr