Synthesis of Dopamines Labelled with13C in the α- or β-Side Chain Position and Their Application to Structural Studies on Melanins by Solid-State NMR Spectroscopy
✍ Scribed by Crescenzi, Orlando ;Kroesche, Christoph ;Hoffbauer, Wilfried ;Jansen, Martin ;Napolitano, Alessandra ;Prota, Giuseppe ;Peter, Martin G.
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 530 KB
- Volume
- 1994
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Abstract
Solid‐state NMR spectroscopy was applied to the analysis of melanins prepared by peroxidase‐H~2~O~2~ oxidation of dopamines specifically ^13^C labelled in the α‐ or β‐side chain positions. A surprisingly diverse pattern of signals indicated the presence of uncyclized dopamine and noradrenaline‐derived units, in addition to indole and carbonyl carbon atoms. These structural features, coupled with the results obtained from elemental analysis of dopamine melanin samples prepared under different conditions, point to a pigment formation process more complex than previously believed. magnified image