Synthesis and NMDA receptor binding of 2-amino-7,7-difluoro-7-phosphonoheptanoic acid
โ Scribed by Christopher F. Bigge; James T. Drummond; Graham Johnson
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 256 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
In an NMDA specific receptor binding assay, 1 had lower affinity than its parent, APH .
๐ SIMILAR VOLUMES
There is now considerable evidence that the N-methyl-D-aspartic acid receptor is important in the genesis of seizures. One of the selective antagonist of the NMDA receptor is 2-amino-7-phosphonoheptanoic acid (APH). In this study we evaluated the effects of intracerebroventricular (i.c.v.) administr
A new method of synthesis of DL-[ 7-14C]indospicine and DL-2-amino-[ 7-1 4C]pimelic acid and their nonradioactive equivalents is reported. The combined radiochemical yield of both compounds, starting from potassium 1 14C]cyanide was 15.3%. Indospicine was isolated as the flavianate.