Synthesis and neuropharmacological activity of 1,2,4-triazine-3-thione derivatives
✍ Scribed by S. S. Smagin; V. E. Bogachev; A. K. Yakubovskii; S. E. Metkalova; T. P. Privol'neva; V. V. Chugunov; É. F. Lavretskaya
- Book ID
- 112397312
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 352 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0091-150X
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## Abstract magnified image 2‐(4‐Substituted aryl)‐4H‐[1,3]thiazolo[3,2‐a][1,3,5]triazine‐4‐thiones (**3a**, **3b**) and 2‐(2‐thiophene)‐4H‐[1,3]thiazolo[3,2‐a][1,3,5]triazine‐4‐thione (**3d**) were synthesized by the reaction of arylisothiocyanates/thiophene‐2‐isothiocyanate with 2‐aminothiazole
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract 4‐Amino‐6‐methyl‐3‐(2__H__)‐thioxo‐5‐(4__H__)‐oxo‐1,2,4‐triazine (**1**) was condensed with 2‐methyl (or phenyl)‐4__H__‐3,1‐benzoxazin‐4‐one (**5a,b**) in boiling acetic acid to give compounds **8‐11**. Reacting 1 with chloroacetyl chloride afforded the corresponding chloroacetamido and