𝔖 Bobbio Scriptorium
✦   LIBER   ✦

2-substituted 4H-[1,3]thiazolo[3,2-a][1,3,5]triazine-4-thiones: Synthesis, crystal structure, and antifungal activity

✍ Scribed by Sohail Saeed; Naghmana Rashid; Peter G. Jones; Uzma Yunas

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
343 KB
Volume
47
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

2‐(4‐Substituted aryl)‐4H‐[1,3]thiazolo[3,2‐a][1,3,5]triazine‐4‐thiones (3a, 3b) and 2‐(2‐thiophene)‐4H‐[1,3]thiazolo[3,2‐a][1,3,5]triazine‐4‐thione (3d) were synthesized by the reaction of arylisothiocyanates/thiophene‐2‐isothiocyanate with 2‐aminothiazole in the presence of tetrabutylammonium bromide as phase transfer catalyst. Compound 3c was synthesized by the catalytic reduction (10% Pd‐C) of 3a. Compounds 3a, 3b, 3c, 3d were characterized by IR, ^1^H NMR, ^13^C NMR, and elemental analysis. All the compounds were tested in vitro against Fusarium solani, A.fumigatus, and Aspergillus flavus using standard drugs. The crystal structure of 3a was determined from single crystal X‐ray diffraction data. J. Heterocyclic Chem., (2010).

📜 SIMILAR VOLUMES

ChemInform Abstract: 2-Substituted 4H-[1
ChemInform Abstract: 2-Substituted 4H-[1,3]Thiazolo[3,2-a][1,3,5]triazine-4-thiones: Synthesis, Crystal Structure, and Antifungal Activity.
✍ Sohail Saeed; Naghmana Rashid; Peter G. Jones; Uzma Yunas 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 22 KB 👁 1 views

## Abstract In search of improved methods to prepare fused heterocyclic triazines by reacting isothiocyanates with nucleophiles, the in situ prepared aroyl isothiocyanates are obtained in high yields by conducting the reaction in the presence of tetrabutylammonium bromide as phase‐transfer catalyst

ChemInform Abstract: Synthesis and Antif
ChemInform Abstract: Synthesis and Antifungal Activity of Some Substituted 1,3,4-Thiadiazolo[3,2-a]-s-triazin-5-phenyl-7-thiones and Imidazo-[2,1-b]-1,3,4-thiadiazol-5-ones.
✍ C. S. ANDOTRA; T. C. LANGER; A. KOTHA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Synthesis and Antifungal Activity of Some Substituted 1,3,4-Thiadiazolo[3,2-a]-s-triazin-5-phenyl-7-thiones and Imidazo-[2,1-b]-1,3,4-thiadiazol-5-ones. -Compounds (III) and (V) are screened for antifungal activity against A. flavous and H. oxyzae. (III) and (V) are more effective against A. flavou