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Synthesis and neuroleptic activity of benzamides. cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds

✍ Scribed by Iwanami, Sumio; Takashima, Mutsuo; Hirata, Yasufumi; Hasegawa, Osamu; Usuda, Shinji


Book ID
111900896
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
880 KB
Volume
24
Category
Article
ISSN
0022-2623

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Synthesis of [carbonyl-14C]- and (methox
✍ Kazuharu Tamazawa; Hideki Arima πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 French βš– 485 KB

## Abstract A new potent neuroleptic agent YM‐09151‐2, N‐[(2RS, 3RS)‐1‐benzyl‐2‐methyl‐3‐pyrrolidinyl]‐5‐chloro‐2‐methoxy‐4‐ (methylamino) benzamide (**10c**), was labeled with carbon‐14 and deuterium for biochemical studies such as metabolism and 14 pharmacokinetics. The synthesis of [carbonyl‐^14