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New potent neuroleptic drugs of benzamide derivatives. III. Structures of YM-09151-1, N-[(2RS,3SR)-1-benzyl-2-methyl-3-pyrrolidinyl]-5-chloro-2-methoxy-4-methylaminobenzamide hydrochloride, and its monohydrate

✍ Scribed by Furuya, T. ;Iwanami, S. ;Takenaka, A. ;Sasada, Y.


Book ID
114503969
Publisher
International Union of Crystallography
Year
1986
Tongue
English
Weight
559 KB
Volume
42
Category
Article
ISSN
0108-2701

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Synthesis of [carbonyl-14C]- and (methox
✍ Kazuharu Tamazawa; Hideki Arima 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 485 KB

## Abstract A new potent neuroleptic agent YM‐09151‐2, N‐[(2RS, 3RS)‐1‐benzyl‐2‐methyl‐3‐pyrrolidinyl]‐5‐chloro‐2‐methoxy‐4‐ (methylamino) benzamide (**10c**), was labeled with carbon‐14 and deuterium for biochemical studies such as metabolism and 14 pharmacokinetics. The synthesis of [carbonyl‐^14