The decasaccharide sialyl-trimeric-Lewis x is a component of glycoproteins and glycolipids that serve as E-and P-selectin ligands. The synthesis of this target structure was accomplished by utilizing a combination of chemical and enzymatic methods. Highlights of the chemical synthesis include minima
Synthesis and Molecular Tumbling Properties of Sialyl Lewis X and Derived Neoglycolipids
β Scribed by Christian Gege; Armin Geyer; Richard R. Schmidt
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 276 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0947-6539
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π SIMILAR VOLUMES
Sialyl Lewis x (sLe x ) derivatives conjugated to readily visualized molecular labels are useful chemical probes to study selectin Β± carbohydrate interactions. Localization of the selectins on the surface of leukocytes and activated endothelial cells can be detected through fluorescence of bound sel
## Abstract __Herein we describe an inhibition study of the sialyl Lewis x (sLe__^__x__^__) expression on a human monocytic cell line (U937), using a series of peracetylated__ N__βAcetyllactosamine (LacNAc) analogues with variation at the aglycon moiety. It was found that the extent of inhibition w