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Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors

✍ Scribed by Valeria Pittalà; Maria A. Siracusa; Maria N. Modica; Loredana Salerno; Alessandro Pedretti; Giulio Vistoli; Alfredo Cagnotto; Tiziana Mennini; Giuseppe Romeo


Book ID
113495364
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
869 KB
Volume
19
Category
Article
ISSN
0968-0896

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Synthesis of novel 5H-Pyrimido[5,4-b]mdo
✍ G. Romeo; F. Russo; A. De Blasi 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 47 KB 👁 1 views

## Abstract A new series of 3‐[ω‐[4‐(4‐substituted phenyl)piperazin‐1‐yl]alkyl]‐5__H__‐pyrimido[5,4‐__b__]indole‐(1__H__,3__H__)‐2,4‐diones (**3–10** and **12–13**) were synthesized from the __N__‐(2‐chloroethyl)‐__N'__‐[3‐(2‐ethoxycarbonyl)indolyl] urea (**1**) or the __N__‐(3‐chloropropyl)‐__N'__