✦ LIBER ✦

Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents

✍ Scribed by Xin-Hua Liu; Hui-Feng Liu; Jin Chen; Yang Yang; Bao-An Song; Lin-Shan Bai; Jing-Xin Liu; Hai-Liang Zhu; Xing-Bao Qi

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 316 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.08.017

No coin nor oath required. For personal study only.

✦ Synopsis

A series of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential telomerase inhibitors were synthesized. The bioassay tests show that compound 3d exhibited potentially high activity against human gastric cancer cell SGC-7901 with IC(50) value of 2.69 ± 0.60 μg/mL. All title compounds were assayed for telomerase inhibition by a modified TRAP assay, the results show that compounds 3d and 3f can strongly inhibit telomerase with IC(50) values of 2.0 ± 0.07 and 1.8 ± 0.35 μM, respectively. Docking simulation was performed to position compound 3d into the telomerase (3DU6) active site to determine the probable binding model.

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