✦ LIBER ✦

Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole as potential antitumor agents

✍ Scribed by Xin Jian Song; Yu Shao; Xing Gao Dong

Publisher: Chinese Electronic Periodical Services
Year: 2011
Tongue: English
Weight: 121 KB
Volume: 22
Category: Article
ISSN: 1001-8417
DOI: 10.1016/j.cclet.2011.05.012

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✦ Synopsis

A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo [3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole is described. This protocol presented such advantages as short reaction time, high yields, simple purification and environmentally benign procedures. Their antitumor activities were evaluated against HL-60 by an MTT assay. The preliminary results indicated that some title compounds exhibit more potent antitumor inhibitory activity than doxorubicin (DOX).

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