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Synthesis and mass spectrometric analysis of hexahydrogenated products of aldosterone, 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone

✍ Scribed by Paulette Bournot; Bernard F. Maume; Prudent Padieu


Book ID
116002184
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
803 KB
Volume
14
Category
Article
ISSN
0022-4731

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A convenient synthesis of 18-hydroxycort
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18-Hydroxycorticosterone and 18-hydroxy-1 l-desoxycorticosterone, were obtained via hypoiodination of 20-hydroxy derivatives. The absolute configurations of the C-20 were established by X-ray, only the 20S alcohols reacted under the hypoiodination conditions.