Synthesis and mass spectra of some 2-carbomethoxy-2-carbomethoxymethyl-2,3-dihydro-4(1H)-quinazolinones
β Scribed by Lemke, Thomas F.; Snady, Harry W.; Heindel, Ned D.
- Book ID
- 127317778
- Publisher
- American Chemical Society
- Year
- 1972
- Tongue
- English
- Weight
- 511 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The solid-phase synthesis of 3,4-dihydro-2(1H)-quinazolinones and 3,4-dihydro-1H-quinazolin-2-thiones is described. Starting from Rink resin, acylation with 4-bromomethyl-3-nitrobenzoic acid and amination with primary amines, reduction with tin chloride and cyclization, the desired 3,4-dihydro-2(1H)
Electrospray ionization (ESI) and tandem mass spectrometry (MS/MS) experiments, as well as electronic impact (EI) and chemical ionization (CI) techniques, have been applied to the title compounds 1a-h. The observation of different fragmentation pathways in the three sets of spectra is in accord with