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Synthesis and Investigation of Conformationally Restricted Analogues of Lavendustin A as Cytotoxic Inhibitors of Tubulin Polymerization

โœ Scribed by Mu, Fanrong; Lee, Debbie J.; Pryor, Donald E.; Hamel, Ernest; Cushman, Mark


Book ID
120515920
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
221 KB
Volume
45
Category
Article
ISSN
0022-2623

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Design and synthesis of conformationally
โœ R. L. Magolda; W. Galbraith ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 969 KB

The use of conformationally restricted phospholipids 1 and 2 has been employed to understand the conformational preference of phospholipase A2 (PLA2) for substrate phospholipids. Inhibition of porcine pancreatic PLA2 with 1 and 2 indicated a two-to fivefold preference for the distal isomer 2 over th