Synthesis and inotropic activity of pyrazolo[4,3-c]pyridine-4-ones and related compounds
β Scribed by Kazuo Ogawa; Kazuhisa Miyoshi
- Book ID
- 102409330
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 393 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
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Some pyrazolo[3,4-c~quinoline-4-ones 1-14 and pyrazolo[3.4-c]quinoline-I ,4-diones 15-17 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The moderate binding activity of 1-5,7,9-10, 13 is attributable to the lack of the optio
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An expedient method for the synthesis of 2-phenyl-5-aryl-2,3-dihydropyrazolo [3,4-b]pyridin-3-ones and 2-phenyl-3-oxo-2,3-dihydropyrazolo[3,4-b]pyridine-5-carbaldehyde in a single-step via condensation of vinamidinium salts with 3-amino-1-phenyl-2-pyrazolin-5-one is described.