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Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-guanidino-Neu5Ac2en (GG167) with modified 5-substituents

โœ Scribed by PW Smith; ID Starkey; PD Howes; SL Sollis; SP Keeling; PC Cherry; M von Itzstein; WY Wu; B Jin


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
955 KB
Volume
31
Category
Article
ISSN
0223-5234

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Novel inhibitors of influenza sialidase
โœ Steven L. Sollis; Paul W. Smith; Peter D. Howes; Peter C. Cherry; Richard C. Bet ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 221 KB

N-Propylcarboxamides la,b-3a,b have been synthesised from 2,3-didehydro-2,4-dideoxy-4amino-N-acetylneuraminic acid 4. The tertiary amides 2a,b-3a,b are highly potent but selective inhibitors of influenza A sialidase. The exceptional inhibitory activity of the dipropylamides 3a and 3b against influen