Synthesis and in vivo evaluation of [11C]semotiadil, a benzothiazine calcium antagonist
β Scribed by Kiichi Ishiwata; Hiroyuki Seki; Kenji Ishii; Shin-Ichi Ishii; Tadashi Nozaki; Michio Senda
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 491 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0969-8043
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## Abstract We demonstrated the synthesis of carbonβ11 labeled 17β__Ξ±__βhydroxyβ11β__Ξ²__β/4β/[methyl]β[1βmethylethyl]βaminophenyl/β17__Ξ±__β[propβ1βynyl]estaβ4β9βdieneβ3βone (RU40555), a selective glucocorticoid receptor (GR) antagonist, and examined the __in vivo__ profile of [^11^C]RU40555. [^11^
An 11C-labeled selective adenosine A2A antagonist, (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-[11C]-methylxanthine ([11C]KF17837), was prepared by reaction of (E)-8-(3,4-dimethoxystyryl)-1,3-dipropylxanthine and [11C]methyl iodide with decay-corrected radiochemical yield of 19-50%, radiochemical pur