Synthesis and in vivo behavior of a copper-64-labeled dithiosemicarbazone derivative coupled to a dihydropyridine carrier

✍ Scribed by Hideo Saji; Akihiko Saiga; Yasuhiko Iida; Yasuhiro Magata; Akira Yokoyama

• Book ID: 102368597
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: French
• Weight: 411 KB
• Volume: 33
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580330207

✦ Synopsis

Abstract

The dihyropyridine ⇄ pyridinium salt redox delivery system was used to develop a perfusion agent that could be labeled with a generator‐produced positron emitter ^62^Cu. A ^64^Cu‐labeled dithiosemicarbazone (DTS) molecule attached to a dihyropyridine carrier (PDTS‐DHC) was synthesized by the simple mixing of ^64^Cu acetate and Zn‐PDTS‐DHC. The latter was prepared by dithionite reduction of the Zn complex of a corresponding pyridinum precursor (PDTS‐QC^+^). When injected into mice, ^64^Cu‐PDTS‐DHC showed a high myocardial uptake and high heart‐to‐blood and heart‐to‐lung ratios. These results demonstrate that it may be possible to develop ^62^Cu‐PDTS‐DHC compounds as radiopharmaceuticals for myocardial perfusion studies using positron emission tomography.