Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor

ChemInform Abstract: Design, Synthesis a

ChemInform Abstract: Design, Synthesis and in vitro Evaluation of Potent, Novel, Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1

✍ Andrian Folkes; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Synthesis and in vi

ChemInform Abstract: Synthesis and in vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-Kinase.

✍ L. C. CREEMER; H. A. KIRST; C. J. VLAHOS; R. M. SCHULTZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

title esters, e.g. (Ib)-(Ie), are synthesized by deacetylation and subsequent reacylation of wortmannin (Ia). In comparison with the latter one, they show superior inhibition of phosphatidylinositol (PI) 3-kinase and increased cell cytotoxicity in vitro. Reduction of (Ib) to (IIa) slightly enhances

Synthesis, in vitro/in vivo Antifungal E

Synthesis, in vitro/in vivo Antifungal Evaluation and Structure—Activity Relationship Study of 3(2H)-Pyridazinones.

✍ Ricardo D. Enriz; et al. et al. 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 76 KB 👁 2 views

ChemInform Abstract: Synthesis and in vi

ChemInform Abstract: Synthesis and in vitro Evaluation of a Series of Diketopiperazine Inhibitors of Plasminogen Activator Inhibitor-1.

✍ Adrian Folkes; Michael B. Roe; Sukhjit Sohal; Julian Golec; Richard Faint; Teres 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

In vitro—in vivo Antifungal Evaluation a

In vitro—in vivo Antifungal Evaluation and Structure—Activity Relationships of 3H-1,2-Dithiole-3-thione Derivatives.

✍ Fernando A. Giannini; Mario L. Aimar; Maximiliano Sortino; Roxana Gomez; Alejand 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 101 KB 👁 2 views

Synthesis and in vitro and in vivo Antif

Synthesis and in vitro and in vivo Antifungal Activity of the Hydroxy Metabolites of Saperconazole

✍ Lieven Meerpoel; Jan Heeres; Leo J. J. Backx; Louis J. E. Van der Veken; Rob Hen 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB 👁 1 views

## Abstract __Herein we describe the scalable diastereoselective and enantioselective syntheses of eight enantiomers of hydroxy metabolites of saperconazole. The in vitro antifungal activity of the eight stereoisomers (compounds **1**–**8**) was compared against a broad panel of__ Candida__spp. (__