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Synthesis and In Vitro Opioid Receptor Functional Antagonism of Methyl-Substituted Analogues of (3R)-7-Hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)†

✍ Scribed by Cueva, Juan Pablo; Cai, Tingwei Bill; Mascarella, S. Wayne; Thomas, James B.; Navarro, Hernán A.; Carroll, F. Ivy


Book ID
111913595
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
1004 KB
Volume
52
Category
Article
ISSN
0022-2623

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Preparation of carbon-14 labeled (3R)-7-
✍ Bertold D. Berrang; Anita H. Lewin; F. Ivy Carroll 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 128 KB 👁 1 views

## Abstract Starting with [^14^C]‐D‐tyrosine, carbon‐14 labeled JDTic dihydrochloride with specific activity 15 mCi/mol was prepared in 5% radiochemical yield. Separation of the (3__R__)‐ and (3__S__)‐diastereomers was carried out via the 3‐phenyl‐2,3,10,10a‐tetrahydro‐5H‐imidazo[1,5‐b]isoquinolin‐