𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and In Vitro Opioid Receptor Functional Antagonism of Analogues of the Selective Kappa Opioid Receptor Antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)

✍ Scribed by Cai, Tingwei Bill; Zou, Zhou; Thomas, James B.; Brieaddy, Larry; Navarro, Hernán A.; Carroll, F. Ivy


Book ID
111913593
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
224 KB
Volume
51
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Preparation of carbon-14 labeled (3R)-7-
✍ Bertold D. Berrang; Anita H. Lewin; F. Ivy Carroll 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 128 KB 👁 1 views

## Abstract Starting with [^14^C]‐D‐tyrosine, carbon‐14 labeled JDTic dihydrochloride with specific activity 15 mCi/mol was prepared in 5% radiochemical yield. Separation of the (3__R__)‐ and (3__S__)‐diastereomers was carried out via the 3‐phenyl‐2,3,10,10a‐tetrahydro‐5H‐imidazo[1,5‐b]isoquinolin‐