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Synthesis and in vitro evaluation of 8-hydroxyquinoline analogs as inhibitors of dental plaque

✍ Scribed by Warner, Victor D.; Sane, Jayant N.; Mirth, Dale B.; Turesky, Samuel S.; Soloway, Barbara

Book ID
121337048
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
385 KB
Volume
19
Category
Article
ISSN
0022-2623

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Synthesis and in vitro evaluation of 8-h
Synthesis and in vitro evaluation of 8-hydroxyquinolines as dental plaque inhibitors
✍ Victor D. Warner; Joseph D. Musto; Samuel S. Turesky; Barbara Soloway πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 389 KB

Some 4- and 5-substituted 8-hydroxyquinolines, with predicted log P values in the range of 1.48-2.90, were synthesized by modified Skraup reactions or thermal cyclization. These hydroxyquinolines include the 5-methyl, 4,5-dimethyl, 4-methyl, 5-hydroxy-4-methyl, 5-methoxy, 5-methoxy-4-methyl, 4-hydro