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Synthesis and in vitro cytotoxicity of cis-(glycolato-O,O′)-[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum (II)

✍ Scribed by Dae-Kee Kim; Jongsik Gam; Hun-Taek Kim; Key H. Kim

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 264 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00126-6

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✦ Synopsis

The synthesis and in vitro cytotoxicity of cis-(glycolato-O,O')[2-substituted-(4R,5R)-4,5bis(aminomethyl)-l,3-dioxolane]platinum(II) are described. Among them, cis-(glycolato-O,O')[(4R,5R)-4,5-bis(aminomethyl)-2,2-diethyl-l,3-dioxolane]platinum(II) (26) was found to be almost equally cytotoxic to cisplatin against two human non-small cell lung cancer cell lines, PC-9 and PC-14, and two human stomach cancer cell lines, MKN-45 and KATO III.

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