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Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives

โœ Scribed by Haiwen Zhang; V. Raja Solomon; Changkun Hu; Gerardo Ulibarri; Hoyun Lee


Book ID
116313840
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
183 KB
Volume
62
Category
Article
ISSN
0753-3322

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Synthesis and in vitro cytotoxicity eval
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A series of trifluoromethylated hexahydropyrimidine and tetrahydropyrimidine derivatives were synthesized and their in vitro cytotoxic activities were determined in colon cancer cell line (COLO 320 HSR). Compounds 4f, 4g, 4k, 5, and 7 proved to be the most active in this series of compounds. They re