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Synthesis and in-vitro Cytotoxic Evaluation of Novel Pyridazin-4-one Derivatives

✍ Scribed by Souad Mojahidi; El Mostapha Rakib; Hanan Sekkak; Said Abouricha; Nouredine Benchat; Hassan Ait Mousse; Abdelmajid Zyad

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
277 KB
Volume
343
Category
Article
ISSN
0365-6233

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## Abstract In the present work 15 new 1,4‐dihydropyridines (DHPs) bearing a coumarin ring were synthesized and assessed on 4 different human cancer cell lines (HeLa, K562, LS180, and MCF‐7). Although, all the derivatives were inactive on LS180 cell line, the results on other cells showed that thes