Synthesis and biological evaluation of n
โ
Jakub Fichna; Kevin Lewellyn; Feng Yan; Bryan L. Roth; Jordan K. Zjawiony
๐
Article
๐
2011
๐
Elsevier Science
๐
English
โ 258 KB
The synthesis and in vitro evaluation of a new series of salvinorin A analogues substituted at the C(2) position with natural amino acids is reported. Compound 12, containing Val, displayed high affinity and full agonist activity at the kappa-opioid receptor. Analogues with bulky and/or aromatic res