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Synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol analogs incorporating natural amino acids

โœ Scribed by Wang, Peng; Bi, Xiu-Li; Xu, Jing; Yuan, Hao-Nan; Piao, Hu-Ri; Zhao, Yu-Qing


Book ID
119963958
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
683 KB
Volume
78
Category
Article
ISSN
0039-128X

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The synthesis and in vitro evaluation of a new series of salvinorin A analogues substituted at the C(2) position with natural amino acids is reported. Compound 12, containing Val, displayed high affinity and full agonist activity at the kappa-opioid receptor. Analogues with bulky and/or aromatic res