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Synthesis and in vitro biological activity of 4α-(2-propenyl)-5α-cholest-24-en-3α-ol: A 24,25-dehydro analog of the hypocholesterolemic agent 4α-(2-propenyl)-5α-cholestan-3α-ol

✍ Scribed by Ho-Shen Lin; Ashraff A Rampersaud; Michael E Richett; Richard W Harper; Lisa S Beavers; Don B McClure; Anthony J Gardner; Patrick I Eacho; Patricia S Foxworthy; Robert A Gadski

Book ID
117214043
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
246 KB
Volume
64
Category
Article
ISSN
0039-128X

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Inhibitors of sterol synthesis. Synthesi
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✍ Edward J. Parish; George J. Schroepfer Jr. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

## Abstract Oxidation of 5α‐cholest‐8(14)‐ene‐3β,7α,15α‐triol with silver carbonate‐celite gave 5α‐cholest‐8(14)‐ene‐7α,15α‐diol‐3‐one in 88% yield. Treatment of the latter compound with tritiated water under basic conditions gave a labeled product which was reduced with lithium tri‐__tert__‐butoxy

ChemInform Abstract: An Alternative Synt
ChemInform Abstract: An Alternative Synthesis of 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, an Intermediate in Sterol Biosynthesis and a Reported Activator of Meiosis and of Nuclear Orphan Receptor LXRα.
✍ B. RUAN; W. K. WILSON; G. J. JUN. SCHROEPFER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

An Alternative Synthesis of 4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol, an Intermediate in Sterol Biosynthesis and a Reported Activator of Meiosis and of Nuclear Orphan Receptor LXRα. -The title compound (V) is synthesized by a simple six-step procedure. A key step in this synthesis is the highly