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Synthesis and in-vitro anticancer activity of 3-cyano-6,9-dimethyl-4-imino 2-methylthio 4H-pyrimido [2,1-b] [1,3] benzothiazole and its 2-substituted derivatives

✍ Scribed by Waghmare, Gangadhar S.; Chidrawar, Anil B.; Bhosale, Vijay N.; Shendarkar, Giridhar R.; Kuberkar, Sharad V.

Book ID
122283779
Publisher
Elsevier
Year
2013
Tongue
English
Weight
394 KB
Volume
7
Category
Article
ISSN
0974-6943

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## Abstract 2‐Amino‐6‐methoxybenzothiazole **1** on reaction with bis(methylthio)methylene malononitrile **2** in the presence of dimethyl formamide and catalytic amount of anhydrous potassium carbonate afforded 3‐cyano‐4‐imino‐8‐methoxy‐4__H__‐pyrimido[2,1‐__b__][1,3]benzothiazole **3**. Under sim

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## Abstract Reaction of 4__H__‐pyrimido[2,1‐__b__]benzothiazole‐2‐thiomethyl‐3‐cyano‐4‐one **(1)** with hydrazine hydrate/aryl hydrazine/heteryl hydrazine in the presence of anhydrous potassium carbonate and dimethyl formamide afforded 3‐amino‐4‐oxo‐(2__H__)/aryl/heteryl pyrazolo[3′,4′:4,5]pyrimido