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Synthesis and in vitro antibacterial evaluation of 1-substituted-4-ethoxycarbonylmethylthiosemicarbazides and products of their dehydrocyclization

✍ Scribed by Agata Siwek; Joanna Stefańska; Irena Wawrzycka-Gorczyca; Monika Wujec

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
180 KB
Volume
21
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

A series of s‐triazoles and thiohydantoines were synthesized by dehydrocyclization of 1‐substituted‐4‐ethoxycarbonylmethylthiosemicarbazides. The molecular structure proposed for s‐triazoles was confirmed by the X‐ray crystal structure analysis of one compound that was prone to crystallization. All compounds were tested in vitro for their antibacterial activity. Some of them showed low levels of activity against Gram‐positive species, MIC range 100–400 μg/mL or higher. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:131–138, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20597

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