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Synthesis and in vitro antibacterial assessment of novel chromones featuring 1,2,4-oxadiazole

✍ Scribed by Santosh D. Diwakar; Ratnadeep S. Joshi; Charansing H. Gill

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
189 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

In search for a new antibacterial agent with improved antimicrobial spectrum and potency, we designed and synthesized a series of novel 3‐((Z)‐2‐(5‐methyl‐1,2,4‐oxadiazol‐3‐yl)‐2‐(4‐nitrophenyl)vinyl)‐4__H__‐chromen‐4‐ones 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h by convergent synthesis approach. All the synthesized compounds were assayed for their in vitro antibacterial activities against gram‐negative and gram‐positive bacteria. The preliminary structure‐activity relationship to elucidate the essential structure requirements for the antimicrobial activity has been described. J. Heterocyclic Chem., (2011).

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Synthesis and antibacterial activity of novel series of 2-(p-tolyloxy)-3-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)quinoline
✍ Ratnadeep S. Joshi; Priyanka G. Mandhane; Wajid Khan; Charansingh H. Gill 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 140 KB

## Abstract A new series of 2‐(__p__‐tolyloxy)‐3‐(5‐(pyridin‐4‐yl)‐1,3,4‐oxadiazol‐2‐yl)quinoline were synthesized from oxidative cyclization of __N__′‐((2‐(__p__‐tolyloxy)quinoline‐3‐yl)methylene)isonicotinohydrazide in DMSO/I~2~ at reflux condition for 3–4 h. The structures of the new compounds w